The crash was on State Route 7, north of milepost 18 in Middleton Township just before 1 a.m.
Troopers say Hudson R. Thompson, 23, of Negley, was driving when he struck a mailbox, sign, ditch, embankment and tree, then overturned and was thrown from his vehicle. He was pronounced dead at the scene.
Thompson was wearing a seat belt, according to the report.
He was driving a 2017 Ford F-350.
ODOT, Negley Fire Department and EMS assisted.